Leukemias

Chronic Myeloid Leukemia


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Co-Editors-in-Chief


Charles M. Balch, MD, FACS
Professor of Surgery, The University of Texas MD Anderson Cancer Center
Editor-in-Chief, Patient Resource LLC
Former Executive Vice President & CEO, American Society of Clinical Oncology
Past President, Society of
Surgical Oncology





Michael A. Caligiuri, MD
President and Physician-in-Chief, City of Hope National Medical Center
Past President, American Association for Cancer Research





David S. Snyder, MD
Emeritus Professor, Department of Hematology/HCT
City of Hope National Medical Center

CML is a slow-growing cancer of the bone marrow and blood that begins when a genetic change mutates or damages early (immature) myeloid cells, which are the cells that become white blood cells (other than lymphocytes), red blood cells or cells that make platelets. Most people who have CML have an abnormal chromosome called the Philadelphia chromosome. It results from an abnormal fusion of two genes, BCR and ABL, which then produces the BCR-ABL protein. It is important to test for the Philadelphia chromosome or the BCR-ABL gene fusion, as some treatments are likely to be more effective.


Other chromosomes may begin to mutate in the accelerated and blast phases. Almost all people with CML will have the BCR-ABL gene detected in their blood or bone marrow.

Classifying CML

Your doctor will use a variety of tests to look for leukemic cells, chromosome abnormalities (which may indicate the Philadelphia chromosome), molecular markers and an enlarged spleen. Those tests may include a complete blood count (CBC) with differential, blood chemistry study, a hepatitis panel (to look for hepatitis B, which can occur with CML), bone marrow aspiration and biopsy, molecular tests, cytogenetic analysis, including karyotyping and fluorescence in situ hybridization (FISH), and imaging tests, including computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound.


The World Health Organization (WHO) classification system is used to classify CML into chronic phase, accelerated phase and blast crisis phase (see Table 2). This helps doctors determine the best treatment and prognosis (predicted outcome after treatment). The phases primarily describe the differences in the number of immature white blood cells (myeloblasts or blasts). Other blood cell count levels and chromosome changes are also considered.


The progression of CML in the chronic phase is generally slow, and it may be several months or years before the next phase is reached. Response to treatment is typically better when the treatment begins in this phase. The most advanced and aggressive phase is the blast crisis phase.


It is normal for bone marrow to contain 5 percent blasts. In a person diagnosed with CML, they blasts are usually higher than 5 percent and indicates a more advanced CML.


Table 1 - WHO Classification System

Phase Description
Chronic Phase Immature (blast) cells make up less than 10% of the cells in bone marrow or blood.
Accelerated Phase This phase is determined by any of the following features:
  • Blast cells make up 10% to 19% of cells in the bone marrow or blood OR
  • Basophils make up at least 20% of the blood OR
  • Very low platelet count not related to treatment OR
  • Very high platelet count that does not decrease with treatment OR
  • Increased size of the spleen OR
  • Increased white blood cell count that does not decrease with treatment
  • Blast crisis phase
  • Blast cells make up at least 20% of cells in the bone marrow or blood.
  • Blast cells rapidly increase outisde of the bone marrow.
  • Large groups of blast cells found in bone marrow biopsy.
  • Used with permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original and primary source for this information is the AJCC Cancer Staging Manual, Eighth Edition (2017) published by Springer Science+Business Media.

    Table 2 - Three Phases of CML

    Phase Key Indicators Symptoms Progression
    Chronic
    (CP-CML)
    Increased number of white blood cells
    None to a few
    Very slow
    (months to years)
    Accelerated
    (AP-CML)
  • Low platelet count
  • Increasing anemia
  • Increase in chromosome abnormalities
  • Fever, poor appetite and weight loss
  • Increasing spleen size
  • Four to six months
    Blast or Blast Crisis
    (BP-CML)
  • Very high white blood count
  • Extra copy of chromosome 8
  • An abnormality in chromosome 17
  • An extra copy of the Philadelphia chromosome
  • Fatigue, fever, poor appetite, weight loss, enlarged spleen
    Without treatment, this phase will develop in about 3 to 4 years after diagnosis.

    Treating CML

    The following options may be used alone or in combination.


    Targeted therapy is the main treatment for chronic phase CML. Targeted therapy that is taken orally (in pill form) is almost always the first line of treatment (meaning the first treatment given) for chronic phase CML. The more advanced stages of CML will usually respond temporarily but quickly require additional treatment; however, when caught in the chronic phase, some patients can receive targeted therapy and remain in remission for many years.


    The BCR-ABL gene is a tyrosine kinase protein that helps CML cells grow, and it can be blocked by a tyrosine kinase inhibitor (TKI). Resistance to this type of targeted therapy can develop in patients; when that happens, several other TKIs are available that may work where others have failed. The response to the TKI therapy (complete response, partial response or no response) can be monitored by a blood test.


    For some patients who remain in remission long enough, your doctor may consider a trial period off of the TKI targeted therapy. This requires very close blood monitoring to look for signs of relapse of the leukemia, but it can allow some patients to stop taking chemotherapy permanently. 


    Chemotherapy may be used for CML that does not respond to targeted therapy or has not improved after treatment with TKIs.


    Stem cell transplantation may be an option, especially when disease is in the accelerated or blast phase (see Stem Cell Transplantation, page 8). Allogeneic stem cell recipients may also receive a donor lymphocyte infusion from the original allogeneic blood stem cell donor to boost the attack on leukemia cells. A donor lymphocyte infusion is used to kill the remaining CML cells that have not gone away completely or have come back following the stem cell transplant.


    Immunotherapy is not typically used as the first treatment for this disease. Cytokine immunotherapy works by introducing large amounts of the laboratory-made cytokines to the immune system to promote specific immune responses.

    Drug therapies for CML

    These therapies may be used alone or in combination.
    bosutinib (Bosulif)
    busulfan (Busulfex, Myleran)
    cyclophosphamide
    cytarabine
    dasatinib (Sprycel)
    hydroxyurea (Hydrea)
    imatinib mesylate (Gleevec)
    nilotinib (Tasigna)
    omacetaxine mepesuccinate (Synribo)
    ponatinib (Iclusig)
    ivosidenib (Tibsovo)
    midostaurin (Rydapt)
    venetoclax (Venclexta)

        As of 10/13/21 

    Relapses or Resistant CML

    The goal of CML treatment is to reach remission, which occurs when leukemia is not detected in the body and there are no symptoms. However, remission may be temporary or permanent. When CML returns, it is called relapses CML. Sometimes, the leukemia does not respond to treatment or stops responding. This is called resistant CML.

    Understanding Blood and Bone Marrow

    Following are some of the components and functions of blood and bone marrow.


    Blood is composed of red blood cells (erythrocytes), white blood cells (granulocytes, monocytes and lymphocytes), platelets and other substances suspended in fluid called plasma.


    Blood stem cells are immature cells that can develop into all types of blood cells, including white blood cells, red blood cells and platelets. They may also be called hematopoietic (pronounced hee-MA-toh-poy-EH-tik) stem cells.


    Bone marrow is the soft, spongy center of some bones, where blood is created.


    Granulocyte is a type of immune cell that has granules (small particles) with enzymes that are released during infections, allergic reactions and asthma. Neutrophils, eosinophils and basophils are granulocytes, which are a type of white blood cell.


    Hematopoietic stem cell is an immature cell that can develop into all types of blood cells, including white blood cells, red blood cells and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow.


    Lymphoid refers to lymphocytes, a type of white blood cell.


    Myeloblast is a type of immature white blood cell that forms in the bone marrow. Myeloblasts become mature white blood cells called granulocytes, which include neutrophils, basophils and eosinophils.


    Myeloid refers to bone marrow and may also describe certain types of hematopoietic (blood-forming) cells found in the bone marrow. Myeloid is sometimes used as a synonym for myelogenous.


    Plasma is the liquid component of blood that carries water, nutrients, hormones, proteins and enzymes to many parts of the body.


    Plasma cells produce antibodies to help fight germs and viruses and to stop infection and disease. They are primarily found in the bone marrow.


    Platelets are blood cells that gather around wounds to form clots and stop bleeding. They also play a part in repairing wounds and creating new blood vessels.


    Red blood cells carry oxygen from the lungs to other parts of the body.


    White blood cells help the body fight infection.

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