Liver Cancer

Clinical Trials

Medical researchers are investigating new therapies and palliative care options that are offering hope for many people diagnosed with liver cancer today. As a result, clinical trials are increasing, making it an exciting time for liver cancer research, especially for advanced stages. Clinical trials are research studies that investigate new therapies and palliative care options with the help of people who volunteer to participate.

Early-phase clinical trials typically assess optimal dose schedules and side effects. Later phase clinical trials typically assess whether or not the new (experimental) therapy is better than already existing therapies.

Current clinical trials in liver cancer are exploring various new combination therapies. Multiple trials are researching whether immunotherapy is best given alone or in combination with another therapy.

Several ongoing trials involve immune checkpoint inhibitors, vaccines and chimeric antigen receptor (CAR) T-cell therapy. Researchers are also searching for new biomarkers to determine good candidates for specific therapies.

Other clinical research includes studies of new screening methods, gene therapy, adjuvant treatment, new surgery techniques, expanding the criteria for liver transplants, determining recurrence risk after surgery and investigating better ways to reduce symptoms and side effects to improve quality of life.

What are Clinical Trials?

  • Clinical trials are medical research studies that are frequently used to test new therapies.
  • All participants enrolled are volunteers.
  • The details of a trial are outlined in the Informed Consent form, which participants must sign before beginning a trial.
  • Participants can withdraw from a clinical trial at any time for any reason.

Myths vs facts

A clinical trial is a last resort. In some situations, a clinical trial may offer the best option among treatments you’re considering and may even be the first option to consider.

If my doctor doesn’t bring it up, I can’t participate. Thousands of trials take place at the same time, making it very difficult for your doctor to know about every trial. That’s why you’re encouraged to search for a clinical trial on your own.

I’ll have to travel to a major city to take part in a trial. Not necessarily. Although people may travel to take advantage of some trials, more are available all over the country in hospitals, treatment centers and doctor’s offices.

Once I start the trial, I have to finish it. Participation is always voluntary. You may choose to leave the trial at any time, for any reason, and opt for standard-of-care treatment.

I’m too old to be in a clinical trial. Seniors may respond differently to treatment and may develop different side effects. Having them enrolled in a trial helps researchers develop the right treatment for older people.

Benefits of Participation

  • Access to leading-edge treatments that aren’t yet available for your type or stage of disease.
  • Higher level of care because you will be closely monitored by your oncologist and the clinical trial medical team.
  • Being an active partner in your own care.
  • Knowing you are contributing to the future of cancer care.

How to Find a Clinical Trial

  • Ask your doctor about available trials for which you may qualify.
  • Search online. Start with this list of clinical trial sites. Depending on your diagnosis, there could be many. Ask friends and family to help.
  • Have your exact diagnosis, pathology report and treatment details available to see if you meet a trial’s criteria.
  • Discuss possible trials with your doctor to determine whether they are an option for you.

Questins to Ask Your Doctor

  • Should I consider a clinical trial?
  • What tests and treatments are involved?
  • Is travel required to participate?
  • Will you continue to manage my care?
  • Will it affect my daily life, such as my capability to work?
  • How long will the trial last?

Clinical Trial Sites


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