U.S. Medical Advisory Board

EDUCATIONAL BACKGROUND

B.A. Yale University, New Haven, CT 1967

M.D. Duke University School of Medicine, Durham, NC 1971

PROFESSIONAL POSITIONS AND EMPLOYMENT

Post-doctoral training (include residency/fellowships)

Surgical Resident Massachusetts General Hospital, Boston, Massachusetts 1971-1973

Clinical Associate, Surgery Branch National Cancer Institute, National Institutes of Health, Bethesda, Maryland (fellowship in urologic oncology) 1973-1976

Urology Resident UCLA, Los Angeles, California 1976-1979

Executive Development Program School of Business Administration, University of Houston, Houston, Texas 1987

Chiefs of Service Program Harvard University School of Public Health, Boston, Massachusetts 1996

Academic positions (teaching and research)

Instructor in Urology UCLA 1978-1979

Assistant Professor of Urology Baylor College of Medicine, Houston, Texas 1979-1982

Associate Professor of Urology Baylor College of Medicine, Houston, Texas 1982-1986

Professor of Urology Baylor College of Medicine, Houston, Texas 1986-1998

Russell and Mary Hugh Scott Professor and Chairman Scott Department of Urology, Baylor College of Medicine, Houston, Texas 1989-1998

Distinguished Service Professor Baylor College of Medicine, Houston, Texas 1995-1998

Professor of Urology Weill Medical College of Cornell University, New York 1998-

Member Memorial Sloan-Kettering Cancer Center (MSKCC), New York 1998-

Head, Prostate Cancer Program MSKCC 1998-

Chief of the Urology Service Murray F. Brennan Chair in Surgery, Department of Surgery, MSKCC 1998-1999

Chairman Department of Urology and Alfred P. Sloan Chair, MSKCC 1999-2006

Member Sloan-Kettering Institute for Cancer Research, New York 1999-

Florence and Theodore Baumritter/Enid Ancell Chair of Urologic Oncology MSKCC 2000-

Professor Department of Urology, College of Medicine, State University of New York Downstate Medical Center at Brooklyn, Brooklyn, New York 2000-

Acting Chief Urology Service, Department of Surgery, MSKCC 2006-2008

David H. Koch Chair Department of Surgery, MSKCC 2006-

Hospital positions (e.g., attending physician)

Senior Attending, Urology, and Chief of the Urology Service (1989-1998) The Methodist Hospital, Houston, Texas 1979-1998

Active Staff, Urology, and Chief of the Urology Service (1989-1998) Harris County Hospital District (Ben Taub General Hospital), Houston, Texas 1979-1998

Senior Attending Urologist St. Luke’s Episcopal Hospital, Houston, Texas 1979-1998

Attending Surgeon Memorial Hospital, New York, New York 1998-

Attending Urologist New York Presbyterian Hospital-Cornell Medical Center, New York, New York 1998-

LICENSURE, BOARD CERTIFICATION, MALPRACTICE

Board Certification

National Board of Medical Examiners, 07/92

American Board of Urology, 1981

Malpractice insurance

Do you have Malpractice Insurance? Yes

Name of Provider: MSK Insurance Ltd.

Premiums Paid by: Memorial Sloan-Kettering Cancer Center

PROFESSIONAL MEMBERSHIPS (medical and scientific societies)

Member/Chair Section 6 Institute of Medicine, National Academy of Sciences (IOM) 1996-

Member American Surgical Association (ASA) 2000-

Member Clinical Society of Genitourinary Surgeons (CSGUS) 1991-

Member American Association of Genitourinary Surgeons (AAGUS) 1988-

Member American Urological Association (AUA) 1982-

Senior Member Society of University Surgeons (SUS) 1982-

Fellow American College of Surgeons (FACS) 1982-

Member American Society of Clinical Oncology (ASCO) 1990-

Member American Association for Cancer Research (AACR) 1996-

Member Society of Urologic Oncology (SUO) 1990-

Member The Society of Surgical Oncology, Inc. (SSO) 1997-

Honorary Member Canadian Urological Association 2001-

Honorary Member The Urological Society of Australasia 1998-

Member Société Internationale d’Urologie (SIU) 1980-

Member Urological Investigators Forum (UIF) 1980-

Member Western Urological Forum (WUFER) 1981-

Member Society for Basic Urologic Research (SBUR) 1987-

Member Society of University Urologists (SUU) 1984-

Member The New York Academy of Sciences (NYAS) 2000-

Member The New York Academy of Medicine (NYAM) 2000-

Member American Medical Association (AMA) 1981-

Honorary Member South CentralSection, American Urological Association (SCSAUA) 1981-1998

Honorary Member South Eastern Section, American Urological Association (SESAUA) 1990-

Member New York Section, American Urological Association (NYSAUA) 1998-

Member New York County Medical Society 2005-2006

Member New York Clinical Society 2000-2002

Member New York Medical and Surgical Society 2002-

Member New York State Urological Society, Inc. (NYSUS) 2000-

HONORS AND AWARDS

Alpha Omega Alpha 1970

First Prize, Scientific Exhibit, American Urological Association 1981

Outstanding Faculty Member of the Year (one of six), Baylor College of Medicine 1985

George Slotkin Honorary Lecturer, New England and Northeastern Sections, AUA, Boston 1985

Leo Roon Visiting Professor, Harvard Medical School, Boston 1986

Gold Cystoscope Award, AUA (awarded to the individual who has contributed the most to urology within 10 years of his residency) 1989

Ballenger Memorial Lecturer and Appointed Honorary Member, Southeastern Section, AUA 1990

Named one of “The 400 Best Doctors in America” by Good Housekeeping magazine 1991

Director, Matsunaga-Conte Prostate Center Research Center, a designation by the National Cancer Institute of the Baylor College of Medicine SPORE (Specialized Program of Research Excellence), the first SPORE in prostate cancer awarded by the NCI 1992

Royal College of Surgeons Lecturer, Dublin, Ireland 1992

Listed in The Best Doctors in America, edited by Steven Naifeh and Gregory White Smith, Aiken: Woodward/White, Inc., p. 519 1992

Eugene Fuller Triennial Prostate Award of the AUA 1995

George Slothin Lecturer, Northeast Section, American Urological Association 1995

Named one of “The Best Medical Specialists” by Town & Country magazine 1995

Elected to the Institute of Medicine, National Academy of Sciences 1996

AUA Lecturer, European Association of Urology Biennial Meeting, Paris, France 1996

American Foundation for Urologic Disease Presidential Award 1996

Named one of “The Best Doctors in America” by American Health magazine 1996

British Journal of Urology Guest Lecturer, British Association of Urological Surgeons Annual Meeting 1997

Royal College Lecturer, Canadian Urological Association 1997

Kaneharu Suzuki Award, Suzuki Foundation for Urological Medicine, Japan 1998

Letter of Commendation from Richard D. Klausner, M.D. (Director, National Cancer Institute, National Institutes of Health) for work done on behalf of the National Cancer Institute’s Prostate Cancer Progress Review Group, Bethesda, Maryland 1999

Gordon Wilson Lecturer, American Clinical and Climatological Association 1999

William P. Burpeau Award, West Orange, New Jersey 1999

Distinguished Alumnus Award, Duke University Medical Center, Durham, North Carolina 1999

Named one of “Best Doctors In New York City” by New York magazine 2000-2003

Featured in TheNew York Times,The Wall Street Journal, USA Today, Washington Post, andThe New Yorker,People, Men’s Health, Forbes,andIn Touch magazines. TV and radio appearances: ABC World News Tonight, NBC Nightly News, NBC Today Show, WNBC Live At Five, WABC - Eyewitness News, WCBS Radio, Health Show - National Public Radioand CBS Network Radio 2000-2004

Keynote speaker, American Association for Cancer Research, New Discoveries in Prostate Cancer 2001

McPeak Lecturer, Society of the Memorial Sloan-Kettering Alumni 2001

Principal Investigator, SPORE in Prostate Cancer, Memorial Sloan-Kettering Cancer Center 2001

AUA Lecturer, Societe Internationale d’Urologie Meeting, Stockholm, Sweden 2002

Presidential Lecturer, Southeastern Section, American Urological Association 2003

Folke Edsmyr Memorial Lecturer and Award, Karolinska Institute, Stockholm, Sweden 2003

Society of Urologic Oncology Medal 2005

Henry Lichtwardt Lecturer, William Beaumont Hospital Graduation, Royal Oak, MI 2006

XXXI Sir Peter Freyer Memorial Lecture, Galway, Ireland 2006

Dr. G.M. Phadke Memorial Oration, Urological Society of India, Patna, India 2007

Whitmore Lecturer, Society of Urologic Oncology 2007

Named one of “The Best Doctors in America,” America’s Top Doctors, Castle Connolly Medical Ltd

Named one of “The Best Doctors in New York,” New York Magazine 2008

Named one of “New York Super Doctors” by New York Times Magazine 2008

Distinguished Contribution Award, American Urological Association 2008

Barringer Medal, American Association of Genitourinary Surgeons 2009

INSTITUTIONAL/HOSPITAL AFFILIATION

Primary Hospital Affiliation

Memorial Hospital for Cancer and Allied Diseases

Other Hospital Affiliations

New York Presbyterian Hospital

Other Institutional Affiliations

Cornell University Medical Center

EMPLOYMENT STATUS

Name of Current Employer(s): Memorial Sloan-Kettering Cancer Center

Employment Status (choose one): Full-time

CURRENT AND PAST INSTITUTIONAL RESPONSIBILITIES AND PERCENT EFFORT

Postgraduate Education Courses Directed

Innovations in Urologic Practice, Postgraduate Course, Baylor College of Medicine 1985, 1987, 1996-1997

Ultrasonography in Urology, Postgraduate Education Course, American Urological Association 1987-1989

Transrectal Ultrasonography for Prostate Cancer, Annual Postgraduate Education Course, Baylor College of Medicine 1988-1989

Urologic Surgery, Post Graduate Course, American College of Surgeons 1990

Prostate Cancer, Annual Postgraduate Education Course, American Urological Association 1990-1997, 1999-2004

New Surgical Approaches in Prostate Cancer, New York Section of the American Urological Association, Barcelona, Spain 2002

Open and Laparoscopic Radical Prostatectomy, MSKCC, New York 2003

Treatment of High-Risk Prostate Cancer, Annual Postgraduate Education Course, American Urological Association 2009

Clinical Care

Outpatient office hours, 2 half days per week 1979-

Operating room, 2 days per week 1979-

Ward rounds, 5 days per week 1979-

Administrative Duties

Baylor College of Medicine

Admissions Committee 1981-1990

Institutional Review Board for Human Research 1983-1986

Chair, Admissions Committee 1987-1990

Director, Residency Training Program, Scott Department of Urology 1987-1996

Education 2001 Task Force 1988-1991

Executive Faculty Committee 1989-1998

Faculty Appointments and Promotions Committee 1990-1994

Research Advisory Committee 1991-1995

Curriculum Committee 1992-1997

Internal Advisory Committee on Center for Molecular Medicine 1992-1998

Search Committee, Director of Center for Gene Therapy 1995

Baylor MedCare Executive Committee and Board of Directors 1995-1998

Vision 2000 Steering Committee 1996

Strategic Planning Committee 1996

Academic Programs Committee 1997-1998

Other Committees

Committee on Review (appointments and promotions), Weill Medical College of Cornell University 2002-2005

Vice Chairman, Biomedical Ethics Committee, The Methodist Hospital 1986-1989

Memorial Hospital for Cancer and Allied Diseases Surgical Executive Committee 1998-1999

Co-Chair, Genitourinary Cancer, Disease Management Team 1998-

Compliance Committee 2000-

Search Committee, Chief of Plastic Surgery 2001

Memorial Hospital Committee on Credentials, Appointments and Promotions (MHCCAP) 2004-

Committee on Appointments and Promotions (COAP) 2006-

Chair, Search Committee for Chair of Pathology 2008

Research

Discovery and validation of tissue markers of progression in prostate cancer

Development of new models of progression and decision-analysis using medical informatics

Longitudinal assessment of health related quality of life in men with localized prostate cancer

Optimizing surgical techniques for prostate cancer

Translational research in prostate cancer

RESEARCH SUPPORT

U01 CA84999-05 Molecular Classification of Prostate Cancer

NCI

$695,361

10/1/1999-03/31/2006

Principal Investigator: WL Gerald

Role: Co-Investigator

5%

Major goals: to define molecular profiles representative of androgen-independent prostate carcinoma by comprehensive, microarray-based gene expression analysis and comparison of androgen-dependent and —independent tumors, to develop robust molecular histopathologic methods to identify and quantitate androgen-dependent and —independent tumor cell subclones within primary human prostate carcinomas, and to analyze the relationship between molecular classification and clinical course of disease.

P50-CA 92629-06 SPORE in Prostate Cancer

NIH/NCI

$1,298,258

9/01/2001-8/31/2011

Principal Investigator: PT Scardino

30%

The major goals of this project are to continue the development of novel systemic therapy for prostate cancer. The development of better prognostic models of lethal variants of early stage prostate cancer and the characterization of important molecular pathways that lead to progression and metastases were designed to support our therapeutic objective by elucidation of specific targets within prostate cancer cells appropriate for mechanism-based therapy. Our central hypothesis has been that the molecular determinants of prostate cancer development and progression vary as the disease evolves.

Prostate Cancer Foundation (Award)

Prostate Cancer Research Program

$1,250,000

7/1/03-12/31/06

Principal Investigator: PT Scardino

% Effort: N/A

Major goal: To identify new tissue markers of progression and metastasis of human prostate cancer, analyze tissue specimens with a systems pathology, high throughput approach and characterize the long-term natural history of clinical localized prostate cancer

T32 CA082088-07 Urology Oncology Research Training Grant (first awarded in 1999)

NCI

$236,632

09/01/1999-02/28/2010

Principal Investigator: PT Scardino

15% effort

Major goal: to produce for the nation a larger cadre of superbly trained clinical scientists to become leaders in academic urologic oncology and who will be highly qualified to promote the revolution of medical care made possible by the developments in modern biomedical science.